1H-Indazole-4-carboxylic acid, 5-bromo-6-chloro-, methyl ester
1H-Indazole-4-carboxylic acid, 5-bromo-6-chloro-, methyl ester
CAS: 1037841-34-1
Molecular Formula: C9H6BrClN2O2
1H-Indazole-4-carboxylic acid, 5-bromo-6-chloro-, methyl ester - Names and Identifiers
1H-Indazole-4-carboxylic acid, 5-bromo-6-chloro-, methyl ester - Physico-chemical Properties
| Molecular Formula | C9H6BrClN2O2 |
| Molar Mass | 289.51 |
| Density | 1.796±0.06 g/cm3(Predicted) |
| Boling Point | 435.0±40.0 °C(Predicted) |
| pKa | 9.99±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | IRRITANT |
| MDL | MFCD13177015 |
1H-Indazole-4-carboxylic acid, 5-bromo-6-chloro-, methyl ester - Introduction
Methyl 5-bromo-6-chloro-1H-indazole-4-carboxylate is an organic compound. Its chemical formula is C10H8BrClNO2 and its molecular weight is 273.53g/mol. The following is an introduction to its nature, use, formulation and safety information:
Nature:
-Appearance: White to light yellow crystalline solid.
-Density: 1.66g/cm³.
-Melting point: 71-73 ℃.
-Boiling point: 317 ℃.
-Solubility: Soluble in chloroform, dichloromethane, benzene and other organic solvents, insoluble in water.
-Stability: relatively stable under general storage conditions, but should avoid contact with strong oxidants.
Use:
-5-Bromo-6-chloro-1H-indazole-4-carboxylic acid methyl ester is often used as an intermediate in the synthesis of other organic compounds.
-It has certain applications in the field of medicine, for example, it can be used to synthesize certain antibacterial drugs and anti-cancer drugs.
Preparation Method:
The preparation method of 5-bromo-6-chloro-1H-indazole-4-carboxylic acid methyl ester can be carried out by the following steps:
1. Methylation of indazole -4-carboxylic acid: Indazole -4-carboxylic acid reacts with methyl iodide under the condition of alkali to generate indazole -4-methyl formate.
2. The reaction generates methyl 5-bromo -6-chloro -1H-indazole -4-carboxylate: methyl indazole -4-carboxylate is reacted with bromine and cuprous chloride (CuCl) in an organic solvent to generate the target product.
Safety Information:
-5-Bromo-6-chloro-1H-indazole-4-carboxylic acid methyl ester is an organic compound with certain risks.
-When handling it, wear appropriate protective gloves, protective glasses and protective mask to avoid direct contact with skin, eyes and respiratory tract.
-Avoid inhaling dust or gas, and maintain good ventilation in the working environment.
-During storage and transportation, the relevant safety regulations should be observed, away from ignition and oxidizing agents.
-In case of inadvertent ingestion or exposure, seek medical help immediately and provide the necessary information to the doctor with the packaging or label.
-Detailed operation and safe use information can be found in the relevant Chemical Safety Data Sheet (MSDS).
Nature:
-Appearance: White to light yellow crystalline solid.
-Density: 1.66g/cm³.
-Melting point: 71-73 ℃.
-Boiling point: 317 ℃.
-Solubility: Soluble in chloroform, dichloromethane, benzene and other organic solvents, insoluble in water.
-Stability: relatively stable under general storage conditions, but should avoid contact with strong oxidants.
Use:
-5-Bromo-6-chloro-1H-indazole-4-carboxylic acid methyl ester is often used as an intermediate in the synthesis of other organic compounds.
-It has certain applications in the field of medicine, for example, it can be used to synthesize certain antibacterial drugs and anti-cancer drugs.
Preparation Method:
The preparation method of 5-bromo-6-chloro-1H-indazole-4-carboxylic acid methyl ester can be carried out by the following steps:
1. Methylation of indazole -4-carboxylic acid: Indazole -4-carboxylic acid reacts with methyl iodide under the condition of alkali to generate indazole -4-methyl formate.
2. The reaction generates methyl 5-bromo -6-chloro -1H-indazole -4-carboxylate: methyl indazole -4-carboxylate is reacted with bromine and cuprous chloride (CuCl) in an organic solvent to generate the target product.
Safety Information:
-5-Bromo-6-chloro-1H-indazole-4-carboxylic acid methyl ester is an organic compound with certain risks.
-When handling it, wear appropriate protective gloves, protective glasses and protective mask to avoid direct contact with skin, eyes and respiratory tract.
-Avoid inhaling dust or gas, and maintain good ventilation in the working environment.
-During storage and transportation, the relevant safety regulations should be observed, away from ignition and oxidizing agents.
-In case of inadvertent ingestion or exposure, seek medical help immediately and provide the necessary information to the doctor with the packaging or label.
-Detailed operation and safe use information can be found in the relevant Chemical Safety Data Sheet (MSDS).
Last Update：2024-04-09 15:17:50
